I’ve been experimenting quite a bit over the last year with CES (tDCS/tACS) to see if I can modify state.I’m encouraged and terrified by the results. For a top level tl;dr I’m pretty confident that I can evoke “depression” and “not depression” states in nearly any subject. It’s all just energy and that energy is fairly easily manipulable, which is the terrifying part.I’ve been baffled by the difference in efficacy between tDCS and tACS however. tDCS across the board generates greater degree of state change at the same current. My assumption is I have a pretty serious flaw in my understanding of flows, probably the assumption that EEG bands are as important as we are assuming.That being said, I’ve also been following several other modalities including low intensity laser, TMS, and ultrasound. Digging into the mechanics of each it appears that the modality isn’t as important as getting the right type (“resonance” as a placeholder word) at high enough levels energy to the right areas. The most consistent issue right now appears to be determining what those right areas are.I’m still looking into this but I think if we decompose our expectation of function to much simpler states (e.g. “depressed” and “not depressed” with depressed here being “high activation of negative afferents” and not depressed meaning “high low activation of positive negative afferents”) it’s likely we are going to find modality doesn’t matter much at all. We may be able to develop this to start targeting specific valence centers, and this might give us the ability to modify state by 25 factors. Variability of construction will make this more difficult, getting personalized EEG to build our models from is going to be critical, but this has more potential granularity than I expected.