Just… wows all around. I figured there had to be clusters like this, even if it was only as ubiquitous as something like Tay-Sachs.
Also, significant protein gunks start building up in the 20’s, and this is probably consistent for most people albeit at a much slower rate. This suggests that once “maturity” kicks in, physiological changes in nervous systems are probably more significant than we realize.
I read something recently about someone in China being diagnosed with Alzheimers at really young age, something like late teens or early 20’s. I was sort of skeptical, however in the context of this I’d imagine it’s not that uncommon, it just doesn’t get diagnosed.
More horrifying is their estimate of dementia progression. We aren’t seeing a population jump. But the rate of this particular “class” of dementia is going to jump by around 2.5 times in about 30 years? How old will you be in 30 years? HOLY SHIT.
I’m still of the opinion that we understand the mechanics of nervous system so poorly that we are dramatically under-representing the effect and only catching SES specific or extreme/advanced effects. Thinking about the high end, 1/4 of the population of the US could be effected by moderate to severe levels of dementia by 2050. It’s fucking terrifying.
Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man