Rather than an out of control metabolic cascade in the case of epileptic activity, this would be represented by a suppression of metabolic activity in a particular region like an “anti-seizure”.
Most analgesics are anti-inflammatories which serve to open up the nerve pipes and reduce subjective pain. If we think about common occurrences of headache related symptoms outside of migraine effects, they all coincide with instances where the pipes would likely be clogged: too much stimuli, not enough rest, ingestion of harmful chemical etc.
Is there a good enough body of PET work with regard to migraines to get a peek at the metabolics here? Does that work have enough resolution to get a good understanding of circuit level interactions yet? Considering this would be astrocytic and nearly invisible on EEG, what other methods could we use to pick up a “hypo-cascade”?
Vocab/Concept – “Cortical Spreading Depression”
Alterations in metabolic flux in migraine and the translational relevance – There’s a Journal of Headache and Pain.
Evidence of cerebral hypoperfusion consecutive to ultrasound-mediated blood-brain barrier opening in rats – Didn’t even think about US imaging.
The putative role of neuroinflammation in the complex pathophysiology of migraine: From bench to bedside – This is getting distressing, is the model really this correct or is neuroscience so shitty that literally any conceit can be supported?
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions – Yeah. Entire nervous system. It’s a system of systems.
Defining metabolic migraine with a distinct subgroup of patients with suboptimal inflammatory and metabolic markers – Building better phenotypical descriptions.
DNA methylation status of interspersed repetitive sequences in patients with migraine – Is medicine even in a place where it’s prepared to prevent harm before it happens? Kind of a minority report moment.
Preclinical Studies of Posttraumatic Headache and the Potential Therapeutics – It blows me away how much MCBs are being tossed at everything these days, we will be able to do some amazing things once these get cheaper.
Role of ATP in migraine mechanisms: focus on P2X3 receptors – Not sold here, especially since this looks like a box checker, but it’s an interesting thing to follow.
Simultaneous 18F-FDG PET/MR metabolic and structural changes in visual snow syndrome and diagnostic use – Temporal cortex hypo-metabolism. Wutang is for the children.