Formal Research Topic – All nervous system cells are glia, neurons are a type of glia
What’s in a name? Defining neurons as the primary nervous system cell type before we had any idea how they function has derailed nearly a century of study. Transcriptonomic analysis demonstrates that neurons come from the same glial progenitor cells as all other nervous system cells. Functional analysis demonstrates that neurons are placed and shaped …
Formal Research Topic – All nervous system cells are glia, neurons are a type of glia Read More »
Rhythms, Oscillations, and CPG dump
Astrocytes regulate locomotion by orchestrating neuronal rhythmicity in the spinal network via potassium clearance
So way out there pondering time…
What if electrical activity in the brain is a coincident indicator of brain function, rather than a primary indicator? One of the huge problems I have thinking about the nervous system in terms of an electrical system is that it’s dogshit slow. Like way slower than you’d expect in a similar system built under the …
“Feelings”, “Emotions”, “Personality”, and “Behavior” should not *ever* be pathologized.
No matter how uncomfortable they make us or society itself. These things are just as instructive to society as they are to the individual, and shape social behavior in the same way they shape individual behavior. We’ve engaged in a massive campaign of suppressing the uncomfortable in society and this suppression has allowed us to …
“Feelings”, “Emotions”, “Personality”, and “Behavior” should not *ever* be pathologized. Read More »
Astrocytes and Epilepsy
Looks like incongruous astrocytic calcium signalling might be the etiology for most types of epileptiform activity. Will edit in place The Effects of Optogenetic Activation of Astrocytes on Spike-and-Wave Discharges in Genetic Absence Epileptic Rats – Gives hope that we might be able to avoid surgery and possibly medications for controlling. Contributions of Astrocyte and …
General Anatomy Dump
The emergence of the calvarial hematopoietic niche in health and disease – Wondering if efficacy of stimulation is modified by these structures? Organization of the ventricular zone of the cerebellum – Yep. Dopamine – Does this belong here? I don’t know. Dopamine is the signal chemical for salience circuitry. Do we have five discrete signaling …
Stimulation
Personal Stimulation Experiments and Data Ref Dump: Whole Body Vibration Improves Spatial Memory, Anxiety-Like Behavior, and Motor Performance in Aged Male and Female Rats – Aids glymphatic clearance, particularly as low frequency waves subside with age? How much does specific frequency matter for efficacy? Test whole sweep down to 1hz cohort style? Does tolerability depend …
High Functioning Autism and Asperger’s Phenotype “functional” deficits may be caused by unusual memory modality rather than systemic function
Main points – These “conditions” represent a significantly different memory mechanic representing the world than “normal”. “HfA” (I need to come up with a better word than “autism”, I’m so done with it) types have an “objectless” memory paradigm and imagine things as collections of properties rather than objects to bind things to. Asperger’s represents …