Author name: foompy_katt

Efficacy vs. Effectiveness

The majority of funding for studying how organisms work comes under the auspices of attempting to “cure” or ameliorate the symptoms of a perceived “disease”. Specifically with regard to neuroscience function, the psychiatric “ordered/disordered” conceit drives an overwhelming amount of the work in the field. We’ve invested hundreds of billions chasing down “cures” for psychiatric […]

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Dementia Villages

Stupid, unnecessary prediction: By 2035 at least 12% of all living individuals will be dealing with moderate to severe dementia related conditions. By the same date, roughly 1% of all individuals will be living in cognitive “intentional communities”. (And yes, high hundreds of millions to a billion+). Also yes, it’s completely incomprehensible right now. First

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Orca Attack!

Isn’t this just the most amazing thing ever? Like we have evidence of non-primate animals not just spreading behavior, but behavior related to abstract concepts/”unnatural” objects. It’s unmistakable evidence that not only are these animals communicating with each other, but doing so with discrete language like constructs across social groups. So much of human ethological

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Brainstem Mini Dump

Distinct neural mechanisms construct classical versus extraclassical inhibitory surrounds in an inhibitory nucleus in the midbrain attention network – Behavior is initiated long before we are “aware” of it, even tasks which supposedly require extensive post processing like visual cues. Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease – Dementias

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An independent regulator of global release pathways in astrocytes generates a subtype of extracellular vesicles required for postsynaptic function

https://www.science.org/doi/10.1126/sciadv.adg2067 Abstract: Extracellular vesicles (EVs) are heterogeneous in size, composition, and function. We show that the six-transmembrane protein glycerophosphodiester phosphodiesterase 3 (GDE3) regulates actin remodeling, a global EV biogenic pathway, to release an EV subtype with distinct functions. GDE3 is necessary and sufficient for releasing EVs containing annexin A1 and GDE3 from the plasma membrane

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Olives Refresher Dump

The time squares sequences: a new task for assessing visuospatial working memory – Olives are pretty tightly coupled to medullar CPG “master” circuits. All sensory data is initially processed in the brainstem, despite the canonical depictions of visual pathways. A disynaptic basal ganglia connection to the inferior olive: potential for basal ganglia influence on cerebellar

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