Author: PhysicalConsistency

  • Dorsal Cognitive Testing

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    PhysicalConsistency
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    Something I’ve been baking in my head for awhile is how to do cognitive assessments which don’t have the subjective tester biases, don’t rely on test security so they can be verified outside of their domain, and directly tests functional units vs. requiring some level of post processing. My brain has been tinkering with the…

  • I am probably wrong about the dementia bomb.

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    PhysicalConsistency
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    The data to support the conceit just isn’t there. There may be small shifts due to things like “diet”, “microplastics” or “alumina” for example, but stopping leaded gasoline alone probably was more impactful than all of those insults combined. More likely what would have presented as dementia will end up being preceded by other disease…

  • February Dump

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    PhysicalConsistency
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    Pons-to-cerebellum hypoconnectivity along the psychosis spectrum and associations with sensory prediction and hallucinations in schizophrenia – Eh, but at least we are looking in the right place now. KCNA2 IgG autoimmunity in neuropsychiatric diseases Brain energy metabolism is optimized to minimize the cost of enzyme synthesis and transport – The title would have been a ton better…

  • Nervous systems don’t differentiate between “action” and “thought”

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    PhysicalConsistency
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    It’s almost certainly accurate to say that all “thought” has the same active “physical” component (salience) as expressed movement does. A big miss we’ve had with regard to the cerebellum prior to the last decade has been the idea that “movement” is a product of separate systems than “thought”. It’s becoming pretty clear that “movement”…

  • Who will weep for Descartes?

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    PhysicalConsistency
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    One of the weirdest parts of being on the internet today is the rush of advertising masquerading as “content” in the form of reviews, articles, backstories, etc that get generated whenever something needs to be uh… advertised. This used to be purely a political thing, we’d get bombarded decades ago with a bunch of different…

  • Is immune response the primary driver of speciation across all dominions of biology?

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    PhysicalConsistency
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    Antigen response is universal to all domains, arguably even/including viruses. “Selection” as an inside out process rather than outside in. “Positive pressure” is an artifact of sympathetic immune response for offspring, “Negative pressure” is an artifact of “incompatible” immune response. Physical attributes are largely irrelevant to the organism itself. As we’ve seen with dogs and…

  • The *literal* stands of experience

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    PhysicalConsistency
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    Ponto-olivary climbing fibers are the substrate upon which all personal experience is built. The neonatal period in humans is largely driven by the linking of these fibers to purkinje cells, which form the basis of conscious experience (predictive processing). The critical period in humans is largely driven by the pruning of connections between these fibers…

  • Is “memory” better thought of as “Sensory Memory” and “Object Memory”?

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    PhysicalConsistency
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    And are these stored discretely? I need to dig around for a bit for the references on these, but there was a bit of research awhile ago linking 4th ventricle CSF impingement to “executive function” degradation. The ventricular zone “VZ” is one of the few places radial glia (stem cells/”neurogenesis”) we’ve been able to verify…

  • Dorsal and Ventral and Everything In-between

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    PhysicalConsistency
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    I’ve been meaning to make a blurb about this for awhile, but it keeps slipping my mind. This means this may be a bit rougher than I intend because I haven’t really thought about how to translate it yet and will probably need to come back and edit quite a bit for errors until I…