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Actually, other way around. Base units would be limited to SGZ/SVZ post puberty/hypothalamic transfer in ventral phenotypes. What a fascinating dynamic, and provides a remarkably coherent mechanical explanation for the shift in learning patterns over a lifespan. Floor is a huge blindspot right now, which is kind of weird because that’s were a lot of …

Are new base memory units increasingly limited to the 4th ventricle post puberty? Read More »

Was thinking a bit about how we could get over some of our information limitations in regard to breadth of data collected, and am wondering if we can replace electrophysiological devices with optical ones? We might even be able to do it fairly cheaply considering COTS sensors can create pixel widths >.5 micron already. There …

Optical in vivo imaging in humans Read More »

Treat this post the same as you would one of the dump posts for now, I’m just spitballing (what a weird idiom) integration of ideas from the past year to see if we can come up with new approaches to current questions. This is going to be edited in place so I’ll start with outlines …

Remodeled Trauma Read More »

It’s becoming pretty clear that when we start showing elevated levels of GFAP or other astrocytic markers in the adult blood stream, it’s an indication that something is going wrong. Work has been done which correlates GFAP level as a biomarker for dementias (from Alzheimer’s to vascular and everything in between), most cancers, renal and …

Should serum GFAP be part of the standard panel for medical physicals? Read More »

Musk’s bid to start Neuralink human trials denied by FDA in 2022, report says The denials themselves are legally confidential to protect investor interests, but I have very little doubt this is true. In their last presentation, it was a total engineering clusterfuck with the head engineer’s biggest insight being that “the brain is squishy”. …

Unnecessary Follow Up: Neuralink human trial authorization denied. Read More »

So this is largely a social commentary, which admittedly is outside of my lane, but it’s a pervasive enough conceit that it’s starting to influence the type and quality of research being produced regarding nervous system function. I won’t beat around the bush, I hate the term “neurodiversity”. It’s a meaningless and harmful conceit which …

Against Neurodiversity. For diversity. Read More »

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies – Looks like the mechanics underlying glial encoding of information to neurons is pretty well preserved. Editorial: Cell biology of brain development and evolution – I’ve been thinking about the developmental effect on infants of sleep in hyperoxygenated/hyperbaric …

All we are is just another dump on the wall (Just a link dump) Read More »

The title is cribbed from one of the most overlooked papers/commentary (IMO) of all time in neuroscience. The article is based on the work of a pediatrician who was investigating the longitudinal effects of hydrocephalus, a condition in which the brain fills up with CSF and this compresses or retards the growth of brain structures. …

Is your brain really necessary? Read More »

If you have a highly weighted ventral fear context (fear of the external harming the self), you probably should avoid this thread. This is not in jest. I wish Reddit had a way to produce a blank page easily. This thread is a work in progress, a continuation of the symbiont/parasite conceit I’ve been on …

Inter-species behavioral signalling Read More »