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I realize that over the last few weeks I’ve left quite a few open posts that I should probably complete. I’ve been having sleep issues the last month (well my kids have, therefore I do as well) so my mental energy has been kind of in the toilet (glymphatic system hasn’t had the opportunity to […]

Actually, other way around. Base units would be limited to SGZ/SVZ post puberty/hypothalamic transfer in ventral phenotypes. What a fascinating dynamic, and provides a remarkably coherent mechanical explanation for the shift in learning patterns over a lifespan. Floor is a huge blindspot right now, which is kind of weird because that’s were a lot of

Was thinking a bit about how we could get over some of our information limitations in regard to breadth of data collected, and am wondering if we can replace electrophysiological devices with optical ones? We might even be able to do it fairly cheaply considering COTS sensors can create pixel widths >.5 micron already. There

Treat this post the same as you would one of the dump posts for now, I’m just spitballing (what a weird idiom) integration of ideas from the past year to see if we can come up with new approaches to current questions. This is going to be edited in place so I’ll start with outlines

It’s becoming pretty clear that when we start showing elevated levels of GFAP or other astrocytic markers in the adult blood stream, it’s an indication that something is going wrong. Work has been done which correlates GFAP level as a biomarker for dementias (from Alzheimer’s to vascular and everything in between), most cancers, renal and

Musk’s bid to start Neuralink human trials denied by FDA in 2022, report says The denials themselves are legally confidential to protect investor interests, but I have very little doubt this is true. In their last presentation, it was a total engineering clusterfuck with the head engineer’s biggest insight being that “the brain is squishy”.

So this is largely a social commentary, which admittedly is outside of my lane, but it’s a pervasive enough conceit that it’s starting to influence the type and quality of research being produced regarding nervous system function. I won’t beat around the bush, I hate the term “neurodiversity”. It’s a meaningless and harmful conceit which

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies – Looks like the mechanics underlying glial encoding of information to neurons is pretty well preserved. Editorial: Cell biology of brain development and evolution – I’ve been thinking about the developmental effect on infants of sleep in hyperoxygenated/hyperbaric

The title is cribbed from one of the most overlooked papers/commentary (IMO) of all time in neuroscience. The article is based on the work of a pediatrician who was investigating the longitudinal effects of hydrocephalus, a condition in which the brain fills up with CSF and this compresses or retards the growth of brain structures.