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Let’s assume that the primary innovation between eukaryotes and prokaryotes is that eukaryotes have the ability to store and compare state information, rather than simply respond to it. Perhaps it’s even appropriate to state that a defining property of eukaryotes is “memory”. In prokaryotes, external influences act directly upon internal processes, e.g. RNA translation is […]

It’s been awhile since I’ve trolled biorxiv, kind of missed getting a “sneak peek at the future” so to speak Astrocytic L-lactate signaling in the anterior cingulate cortex is essential for schema memory and neuronal mitochondrial biogenesis – Makes sense, and kind of cool work, can’t wait to see this in the journals. If an

I’ve goofed on this topic pretty hard in the past, and still continue to make clarity goofs, so this is partly an explainer for myself to check concept coherence. Will source this up later. Central pattern generators are astrocytic circuits which create a baseline rhythmicity to brain function. This rhythmicity allows functional groups in nervous

Had a thought that with increased understanding of the metabolic interactions in biological systems, we likely will be able to generate compounds which disrupt the metabolic cascade in only a single person (or at least a really compact phenotype, maybe family?) and the odds of it being detected are almost non-existent because the effect group

Chemical modification of behavior isn’t exactly a novel idea. It’s currently the backbone of psychiatry, the idea that we can chemically induce desirable behaviors with an “anti-depressant” or “anti-psychotic”. And sometimes it even works! I was reading about a new class of weight loss drugs including Tirzepatide (which is getting fast tracked as a breakthrough

Since underlying all of these processes are the same changes expression rates of relevant peptides/proteins, we should be able to use the same stimulation techniques to modify non-brain areas. For example, a body builder should be able to use an ultrasound or tDCS style rig over a specific muscle group to enhance exercise performance and

Or more appropriately, a need for funding based on social/philosophical constructs which has stripped it’s ability to be skeptical.

https://www.cambridge.org/core/journals/cambridge-archaeological-journal/article/an-upper-palaeolithic-protowriting-system-and-phenological-calendar/6F2AD8A705888F2226FE857840B4FE19 This is pretty amazing for a few reasons IMO. This is a history altering revelation that likely would never have been achieved had it not come from outside the assumptions of the “scientists” who study archaeology/anthropology. (I have scientists in quotes here because both of these topics are built almost entirely on conjecture, with

Heard part of an interview with the author on NPR a few weeks ago (I think) and he seemed like a genuinely curious person, so I have pretty high hopes for this one.I only have a few more books in mind, so any suggestions are welcome going forward.AmazonWorldCatOverDriveLibgenShort Review: This is an amazing book, an