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First, I hate the term, I hate the definition, I hate how it’s evaluated. And that’s interchangeable with a whole host of verbs, like loathe. Unfortunately, we’re still in Rome and to be an effective Vandal alternatives are required. Also, this might be a bit chaotic because it’s pulling from concurrent lines of evidence, so […]

Heard a radio ad a few hours ago looking for class action participants who took Tylenol during pregnancy and had a child later diagnosed with “autism”. Tylenol has long been associated with lots of different conditions, and I usually wrote this off because the use of both it and ibuprofen is so pervasive that actual

Low-Carbohydrate and High-Protein Diet Suppresses Working Memory Function in Healthy Mice HEH. DCX expression disorders usually result in “Smooth Brain” conditions. Wonder if there’s an association between dementia and keto style diets. It seems like the MoA for a lot of “meathead” diets is suppression of dorsal function. This work is interesting because it illustrates

Eukaryote cells are hybrids, they use both anaerobic and aerobic metabolic components. Aerobic processes allow for more raw energy, sustained over time. Underlying those processes are anaerobic processes, which are the basis nuclear<->cytoplasmic metabolic interactions. We need a way to accurately measure these processes outside of assumptions derived from BOLD style conceits. Got sidetracked thinking

Currently, many of our cellular definitions are based almost entirely on their visual appearance. Why is a neuron a neuron? Because it looks like a neuron. This tautological understanding of nervous system cells (it’s a neuron or not a neuron) over the past 100 years has carried increasing amounts of weight (and disconnect from actual

Think of intercellular communication between cells in brains along the lines of how language itself works. Our “neurotransmitters” work very similarly to “language” as a whole, e.g. GABA being “English”, and Glu being “Spanish”, and Serotonin being “French” or whatever languages you prefer if you aren’t in North America. They provide the baseline structure and

Moving beyond the definition of biological life, what universal properties exist between all conceptions of “life” (including xeno concepts)? For example, is self sustaining metabolism a universal property? If so, are stars “alive”? Are galaxies alive? If not, why, considering biological life is a subset of those physical interactions? We are biased toward the chain

Assuming that ventral dominant brains allow for “filling in the gaps” of sensory information in a more efficient way, human brains were less metabolically intensive than extant species like Neanderthalensis. During adverse environmental conditions which presented challenges to achieving the necessary calories to support those big brains, Sapiens were able to shift more work to

CA2 orchestrates hippocampal network dynamics – This is a good summary because it breaks out of the “social” box that most work focusing specifically on the CA2 region seem to be stuck in. Fluoxetine Enhances Synaptic Vesicle Trafficking and Energy Metabolism in the Hippocampus of Socially Isolated Rats – It’s weird to think of “happiness”