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If we were going to solve some of the problems that the Neuralink team is trying to address, what pathways show the most promise? First, from a construct perspective, the device itself needs to philosophically be viewed as an astrocyte/oligo package. In conditions like Parkinsons (side rant: I really wish medicine would get over naming…

In Case You Missed It: https://www.youtube.com/watch?v=YreDYmXTYi4 You didn’t miss much. The team is so engineering heavy that they have no path toward making any genuine breakthrough on the physiological end because they are assuming nervous systems are simple electrical bleep bloops. I think the most telling part of the whole presentation was when one of…

Edit: What’s the difference between drunk and demented on small timescales? I’m wondering what the range of calcium channel performance looks like across a population. What do the phenotypes for Ca2++ and Ca2– look like? Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance

One of the goals of this project is to get a better understanding of how behavior works from a pure physiological perspective, such that we have the ability to optimize social inputs for an individuals particular preferences (or “strengths and weaknesses”). This is also meant to provide a consistent basis to the testing like competitive…

The second most privately asked question I get asked is what is all this for? What’s the purpose? And most people are surprised/skeptical that my response is something on the order of “I’m not really interested in this topic, but it needs to be done”. Being a bit more concise, this field caught my was…

This assumption is a primary conceit of most neuro research. The evidence to support it is weak at best, contradictory at worst. Increased firing without an attached metabolic effect, that is without a specific peptide/protein/chemical reaction, is spinning a wheel. It’s a pulse with no message. We have a significant body of evidence that demonstrates…

It’s funny how fast things can go from “I’m so understimulated I feel like I’m turning into a tree” to “Oh god oh god oh god”. Despite the stress, I’m grateful for times like these because they force critical examination of priorities and resource allocation, and usually provide a path to a more clear/pure set…

We are already starting to hit critical points with regard to helium supply, however we’ll soon be hitting critical points with regard to supply of other materials used in other computer aided imaging techniques. Without significant innovation, we’ve likely hit the field cap for widespread MRI at 7T, which still isn’t good enough. Eventually even…

https://pubmed.ncbi.nlm.nih.gov/31850135/ Aim: In this paper, inspiring Darwin’s theory, we propose a model which connects evolutions of neural circuits with evolutions of cosmos. In this model, in the beginning, there are some closed strings which decay into two groups of open strings. Methods: First group couple to our universe from one side and produce matters like…