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Insight into the Mammalian Aquaporin Interactome Tau target identification reveals NSF-dependent effects on AMPA receptor trafficking and memory formation AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models The structural coverage of the human proteome before and after AlphaFold The AlphaFold Database of Protein Structures: A Biologist’s Guide Optogenetic…

Popular models of how “memory” works makes as much sense to me as most theodicies. Even with constructs like engrams, where we assume that certain configuration of electrical pulses get magically integrated into something coherent somewhere else in the network is really incoherent in the face of the evidence. “Memory” is a consistent and necessary…

The traditional model of senses usually splits them up between five to seven distinct units, sometimes segregated by receptor, sometimes segregated by perception. Thinking about how to generalize these out in a consistent way, I think it might be more accurate to think about them in terms of Mechanical Waves, e.g. touch and sound, chemical…

Finally have the website software up, so my goal is to start migrating appropriate content there (https://www.remodeledbrain.com) as time permits. Sub will be remain up, and I’ll probably continue using it as a scratchpad, but in order for it to remain useful I don’t want it devolving into every other neuro related sub if it…

Salience provides the impulse, analogous to “flight/fight/freeze”. Valence tuning provides the behavior, “Run there”, “Yell”, “Play Dead”. Valence can modify the salience pulse, e.g. “freeze” can be modified to “fight” with high enough metabolic output through “positive” valence channels. Valence and salience combinations can produce unstable/highly error prone combinations which are “felt”, e.g. anxiety. For…

An early origin of iron–sulfur cluster biosynthesis machineries before Earth oxygenation A Cofactor-Based Mechanism for the Origin of the Genetic Code

Redefining the Catalytic HECT Domain Boundaries for the HECT E3 Ubiquitin Ligase Family Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems Widespread autogenous mRNA–protein interactions detected by CLIP-seq Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function Changes in chromatin accessibility are not concordant…

Are dopamine, serotonin, etc “training” chemicals that help establish pathways rather than active signalling chemicals? Specifically, they work like something closer to “traffic lights” while peptide binding to astrocytes determine the actual “information” being transmitted. This indicates that the integrative process is mostly a reconfiguration of peptides integrated upward. Mechanically, this provides an actual non-magical…

Editorial: CNS pain circuits in health and disease – The perception of pain is gated by level of associated valence. Neurokinin-1 Receptor-Immunopositive Neurons in the Medullary Dorsal Horn Provide Collateral Axons to both the Thalamus and Parabrachial Nucleus in Rats – Tree walk, supporting the medulla as initiation point of salience. So, it looks like…