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I’ve been really interested in techniques which reverse the specialization of cells, especially work around inducing pluripotency in existing cells. Outside of mature red blood cells, nearly every cell in the body has all of the instructions necessary to devolve into a pluripotent state, and most research I’ve read indicates that those pluripotent cells will…

I’ve held for awhile that the science supporting this conceit is iffy, my feeling has been that at best it provides a way to mitigate some of the accumulated environmental insults of living. The mechanics of how such a thing could work mechanically had been out of reach which seems bizarre for something so systematic.…

Ugghhhhhgghhggh to me for making this. Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior – wow.

At the cellular level, agency exists. Up to billions of cells coordinate agency to create an organism (like humans). And up to billions of organisms coordinate to create a species. And billions species coordinate to make an ecosystem. The “magic” of life is it’s mechanics of cooperation. “Memory” is novelty transposed against the ordinary. Facts…

Thinking about the effectiveness of lithium for cycling “disorders”. Does lithium hijack NKA pump? Seems like it steps on one side of the pump. What does it feel like on lithium while bipolar? It’s weird how deep in the well it’s necessary to go when trying to find the effects of these substances on “normal”…

My goal this week is to get the website for this project setup. I’m liking the theme of “Moving beyond magic”. I realize that my recent focus has been on glia specifically, but my hope is to expand it to any understandings which meet decent scientific rigor. One connundrum I’m having is what to do…

These are the words I use in my current RSS filter, please recommend any I should add or remove! “Astrocytes” “Tanycytes” “Microglia” “Autism Brainstem” “Autism Brain Stem” “Autism Cerebellum” “Autism Hypothalamus” “Autism Hippocampus” “Dorsal Ventral Stream” “Hypothalamus” “Deep Cerebellar Nuclei” “Dentate Nucleus” “Emboliform Nucleus” “Globose Nucleus” “Fastigii Nucleus” “Pedunculopontine” “Locus coeruleus” “WNT wingless” “SHH hedgehog”…

Processing mechanics Possibly five total? “Intra” and “Sub Intra?”

Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling (“Disease”. Jesus Christ.) Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses Okay, this gives us a specific gene to follow for system wide effects. If we see system wide effects, then…