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Remade thread to combine Alzheimer’s, Parkinson’s, and likely all dementias. Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden Calcium signaling in individual APP/PS1 mouse dentate gyrus astrocytes increases ex vivo with Aβ pathology and age without affecting astrocyte network activity Aging, Cellular Senescence, and Alzheimer’s […]

Focus on Reticular formations, link back to pathology dumps?

This is probably going to probably end up being explored under our “autism” map, but what do localized area of hyper and hypo function look like in brains? Could “schizophrenia” be a type of associative hyper or hypo function? Could sensory sensitivities be the product of brain stem hyper/hypo functionality? How do we assert an

Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions This is a nice baby step along the path to converting the study of brains from phenomenological to physiological. One of the important bits for me is the sheer breadth of inputs, this supports the construct of brain function having

My brain has been noodling around with the concept of multidimensional representations of “reality”, particularly how our brain manipulates our two dimensional perceptive ability into this experience which feels so “complete(?)”. I came across a paper on optics and it linked back to information about camera obscura and that to the mechanics of how our

I recently read a book which attempted to map out the route from the beginnings of biological function to “consciousness”. While the book itself didn’t work out because it hand waved “consciousness” into existence, what it did do was provide a glimpse at how “decisions” can be generated via “basic” biological constructions. How sensitive to

Are humans viable with more than 7 copies? Do CNVs cluster in regions which govern development which is particularly sensitive to environment? Are CNVs a type of valence signal for a particular trait? If so are there “opposing” valence signals embedded elsewhere in the genome?

Astrocytes in Post-traumatic Stress Disorder Astrocytes and neuropsychiatric symptoms in neurodegenerative diseases: Exploring the missing links Factors Associated With Patient-Reported Postsurgical Symptom Improvement in Adult Females with Chiari Malformation Type I: A Report from the Chiari1000 Dataset The executive functions, intellectual capacity, and psychiatric disorders in adolescents with Chiari malformation type 1