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One of the most confounding and frustrating things in brain research has to be seeing a hypothesis that looks very promising in animal models fail to translate to humans (or even other animals). Why is there such a consistent disconnect between promising research and real world application? To survive challenges over replicability teams rely on […]

They don’t love you like I love you. I’ve been thinking about hippocampal place, space, and prediction maps the last few days and realize that this construct of maps must be pretty pervasive for dorsal dominant thinking, and the overweight stapling function in the CA1 region is probably the genesis of why my thinking patterns

I suppose this thought was the genesis of this subreddit, but this question has really started coming into focus over the last few days for me. We have these extremely top level concepts and assumptions, but for most people understanding how they’ve formed any particular behavior beyond the most top level experience is a complete

Controlling absence seizures from the cerebellar nuclei via activation of the Gq signaling pathway What does it look like when we tweak the DCN side/Cerebellum side of the equation? Early Cerebellar Development in Relation to the Trigeminal System I really wish there was more of this early developmental data available, understanding the developmental priority adds

One of the most persistently frustrating things for me is how poorly we understand what “normal” or “healthy” brain function looks like, despite the fixation on what is “unhealthy” or “disordered”. Not to get too Maslow here (or maybe), the obsession with crippled brains is resulting in crippled philosophy. I started researching brains in general

Something which has been bugging me recently is the mechanics of “unconscious” behavior. My current model for this is that unconscious behavior represents well defined engrams for the behavior which needs to be executed, and requires subthreshold energy activation for loading into consciousness. I think current evidence supports the formation of engrams via reverse hebbian

Ventral hippocampal shock encoding modulates the expression of trace cued fear Whoa, there’s a TON in this one and I need to follow up on, but this bit caught me by total surprise: Contextual fear learning was largely intact, although a subset of animals in each sex were differentially affected by shock-silencing. A meta-analysis of

Are some genetic traits flexibly encoded via sperm? Is this a selective mechanic which enables greater response to environmental conditions? Crap, should have said engram ensembles instead of behavior. Poopy! Edit: Specifically, if engrams are flexibly encodable in DNA via male sperm, exactly what types of engrams can be encoded, what level of complexity can

This study was recently released regarding lead exposure and it’s cumulative impact on “IQ” in the United States. The impact of it is absolutely staggering, nearly a billion points of IQ wiped out to make engines quieter. There’s a significant chance that might be an under estimate of the impact. In another perspective, this is