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(work in progress) Post SSRI/SNRI sextual dysfunction (PSSD) information is still recent and underreported, despite the long term use of many classes of drugs. What is PSSD? How often does it occur? Are patients and physicians fully aware of the risks? What impact on quality of life does it impart? How often are PSSD related […]

Chemogenetic activation of Locus Coeruleus Noradrenergic Neurons Modulates the Default Mode Network My model has the LC as primary initiation point for the dorsal stream. Modulating activity of frontal areas by manipulating the LC is expected behavior. Correcting the Hebbian Mistake: Toward a Fully Error-Driven Hippocampus Hebbian learning in general has always bugged me for

My last few posts regarding anticholinergic/antipyschotic/antidepressant drugs have been really eye opening, particularly the reaction to them. It’s been pretty baffling to me that people would so vociferously defend a psychiatric/medical system that so clearly has failed to achieve it’s own stated objectives. Why would someone accept 5 diagnoses as gospel while simultaneously acknowledging none

Apologies for any typos, any feedback on where gaps need to be filled in would be much appreciated. Related Series: Are psychiatric drugs driving dementia rates? Efficacy and safety of psychiatric drugs Fertility and Birth Rates have been falling or stagnant since the 1970’s A ‘New’ Normal? An Updated Look at Fertility Trends Across the

(Similar to everything else, WIP) How effective are our current treatments for depression? Divergent Outcomes in Cognitive-Behavioral Therapy and Pharmacotherapy for Adult Depression Cognitive-behavioral therapy (CBT) and pharmacotherapy are, on average, equally and moderately efficacious acute-phase treatments for unipolar depression. For example, 50%−60% of patients receiving CBT or pharmacotherapy for depression respond, compared with 40%

(Ugh, way too many things I need to update now) Echolalia occurs due to lack of hemispherical dominance in autistic brains. Individuals are aware of both the dorsal and ventral interpretation of the sound and bounce them back in an attempt to reconcile/integrate the “sound” (phonological) and “context” (lexical/semantic) of words/phrases. Autistic brains are able

(Will be editing in place) Primary reason for sleep is re-establishing homeostasis in feed forward circuitry. Association/Integration are not integral reasons for sleep, dreams are unchecked ventral stream prediction (hallucinations). This looks like it’s phenotype dependent apparently. It’s not sleep so much as the ability to push delta waves, and most people can only push

(Will be editing in place) Molecular mechanisms of autism: a possible role for Ca2+ signaling Increased Ca2+ signaling in NRXN1α+/− neurons derived from ASD induced pluripotent stem cells Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice Postnatal developmental changes in Ca2+ homeostasis in supraoptic magnocellular neurons Edit: Astrocyte-derived ATP:

(Will be editing this in place). Astrocytes and Behavior Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1 Recent insights on astrocyte mechanisms in CNS homeostasis, pathology, and repair Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and