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Anticholinergic drugs are among the most widely prescribed class of drugs today, used in the treatment of conditions from motion sickness to psychosis. Of the two 200 most prescribed drugs, a significant portion of them are Anticholinergic. I have limited the following studies to within the last two years, honestly because it was too depressing …

Anticholinergic drugs cause dementia, lead to worse outcomes than those not taking them. Read More »

Okay, trying out a new methodology for “ADHD” management, but it’s really slow and arduous. For the last two days I’ve been making it a point to type every single step I take in any multi-step process. At work for example, “User name” “Tab” “Press Enter”, etc. When cooking, type out the exact process, “turn …

“ADHD” specific experiment Read More »

Let’s assume that valence/salience proves correct. This would allow use to re-target our understanding of these conditions to issues with either an imbalance of valence and/or salience targets, or lack of a target altogether. A common form of depression, “Habenular depression”, would indicate that a salience signal was not being processed in the habenula. This …

New Treatment Modality for “Motivation” and some types of “Depression” under the Valence/Salience model Read More »

I probably still need to more clearly illustrate the “dorsal” vs. “ventral” streams first, however I’ve been looking at these function groups through the lens of the more/less/modulate framework, and going circuit by circuit it appears the function of these two streams is segregated along this split. My expectation was that dorsal streams could generate …

Are dorsal and ventral circuits perform “valence” and “salience” respectively? Read More »

Scratchpad – To be updated in the coming week Most cyclic “conditions”, including Bipolar, Unipolar, Depressive Disorders with Recurrence, etc are the result of issues with high level homeostatic control circuitry, the overwhelming majority being in the hypothalamus and putamen/globes. There will also be a similar control system located in the brain stem for brain …

Cyclic Conditions are homeostatic control issues. Read More »

This is just a sketch pad for this topic, planning on filling it out over the next few weeks. This is a look at some “ADHD” types, some “OCD” types, some “Schizophrenia” types, and also certain types of dementia. Jist is that each of the major subsystems has a carrier wave which is combined together …

Synchronicity Read More »

How Our Cells Become Our Selves: The Cellular Phylodynamic Biology of Growth and Development A look at the developmental process from the cellular level of animal life.

The core, inviolable posit is that all biological computation is a convolution of a “more/less/modulate” basic function. That is a positive afferent, attractor, etc and a negative afferent, repeller, etc. I like to think of this as “want”/”don’t want”/something else, if you are a behaviorist you might like framing basic behavior down to “fight(more)” “flight(less)” …

A proposed new model of brain function Read More »