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The idea has been percolating in my brain for a few weeks that our understanding of “how DNA works”, particularly in regard to expressed behavior, might rest on similar philosophical pitfalls that led to the over application of neuron function in the study of nervous systems. We’ve assumed that DNA construction guides expression because we…

Been thinking quite a bit lately about the mechanics of how DNA and RNA interact, and more specifically how RNA is constantly shaping DNA in response to external environment. I’ve been caught up on the idea that every cell in every organism is the result of a sustained chemical reaction stretching back billions of years…

One of my favorite youtube channels Thought Emporium has started series of shorts which explore the pathfinding/maze solving abilities of single celled organisms. A very cool look at biological science possibilities outside of the lab, and an illustration of how anyone can replicate existing science to verify their expectations/predictions. Short 1 Short 2

Open to volunteers and/or ideas here. I spun up this forum mostly as a place where I could scratchpad ideas based on a ground up follow the data kind of approach mostly because I was kind of shocked at how ineffectual current neuro/psych understandings are in predicting anything useful. The primary impetus of the site…

Ermagerd. The tl;dr is that astrocyte networks transmit interdependently of neurons and represent a discrete signalling network. Astrocytes also have the ability to modify activity of neurons in completely different regions (can control the entry and exit of a signal). Edit: Astrocyte domains and the three-dimensional and seamless expression of consciousness and explicit memories –…

DNA Methylation and Establishing Memory – I don’t recall reading this paper, but it’s so sympatico with the RNA based memory/mechanics of stimulation posts I’ve made. It’s still stuck on the neuronal/cortical models, but it’s a good introduction to the concept of how RNA create engrams and how stimulation (like tDCS) may modify behavior even…

‘MTL knew’: Misconduct allegations independently corroborated in private correspondence to special committee They finally flagged the paper – APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Stanford University president announces resignation over concerns about his research Over 800 citations, with the most recent coming within the last few months.

Astroglial Alterations in the Hippocampus of Rats Submitted to a Single Trans-Cranial Direct Current Stimulation Trial – Lol, I guess I haven’t posted anything about tDCS for awhile but it looks like there’s finally some scant support for my hypothesis about it’s effectiveness. Reading very slightly between the lines, this work implies that tDCS modifies…