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Efficacy vs. Effectiveness

The majority of funding for studying how organisms work comes under the auspices of attempting to “cure” or ameliorate the symptoms of a perceived “disease”. Specifically with regard to neuroscience function, the psychiatric “ordered/disordered” conceit drives an overwhelming amount of the work in the field. We’ve invested hundreds of billions chasing down “cures” for psychiatric …

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Dementia Villages

Stupid, unnecessary prediction: By 2035 at least 12% of all living individuals will be dealing with moderate to severe dementia related conditions. By the same date, roughly 1% of all individuals will be living in cognitive “intentional communities”. (And yes, high hundreds of millions to a billion+). Also yes, it’s completely incomprehensible right now. First …

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Orca Attack!

Isn’t this just the most amazing thing ever? Like we have evidence of non-primate animals not just spreading behavior, but behavior related to abstract concepts/”unnatural” objects. It’s unmistakable evidence that not only are these animals communicating with each other, but doing so with discrete language like constructs across social groups. So much of human ethological …

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Glia Dump Part 39, almost but not quite

Neuron-astrocyte omnidirectional signaling in neurological health and disease – It’s kind of shocking how far we’ve come in the past 15 years, and kind of disorienting to realize there’s still no indication of how far we need to go. This is a pretty good review of that! Differential intracellular trafficking of extracellular vesicles in microglia …

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Brainstem Mini Dump

Distinct neural mechanisms construct classical versus extraclassical inhibitory surrounds in an inhibitory nucleus in the midbrain attention network – Behavior is initiated long before we are “aware” of it, even tasks which supposedly require extensive post processing like visual cues. Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease – Dementias …

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An independent regulator of global release pathways in astrocytes generates a subtype of extracellular vesicles required for postsynaptic function

https://www.science.org/doi/10.1126/sciadv.adg2067 Abstract: Extracellular vesicles (EVs) are heterogeneous in size, composition, and function. We show that the six-transmembrane protein glycerophosphodiester phosphodiesterase 3 (GDE3) regulates actin remodeling, a global EV biogenic pathway, to release an EV subtype with distinct functions. GDE3 is necessary and sufficient for releasing EVs containing annexin A1 and GDE3 from the plasma membrane …

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