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The valence systems are much much much more sensitive to external training, are some people untrained to use their valence systems? We can create model behavior, but what happens when stimuli exceeds the model, how do individuals react? Are we experiencing an increasing failure to address out of bounds events during the developmental process due …

Are many “mental health” issues etiologically weak or disrupted valence? Read More »

We do not experience the world, only our reaction to it. Examples: Nervous systems do not store “ball” or “sound”, they encode the physiological responses to those stimuli which are constructed into objects via downstream processing. This bridges the “stimuli == memory == behavior” conceit. How do sensory illusions work? Oh wow, the thing where …

Next significant model prediction: Nervous systems do not directly store stimuli, only “reactions” to stimuli Read More »

(shit, should have typed “nervous systems”) (also have to stop reverse Betteridging stuff, it’s a dumb habit) Imaging the electrical activity of organelles in living cells Lysosomes as dynamic regulators of cell and organismal homeostasis A lysosome-centered view of nutrient homeostasis – Some interesting arguments despite the age. The direct piezoelectric effect in the globular …

Is electricity in brains an artifact of lysosomal metabolic activity chains rather than a primary mechanic? Read More »

(WIP) Life does not happen without stimuli. It becomes alive only through the constant metabolism/catalysis with “the world” external to the cell (or whatever we define as the minimum quanta of life for the virus/RNA/RNP fans). The action of this metabolic/catalytic process, which serves as the foundation of our definition of biological life, is the …

The equivalence of Stimuli – Memory – Behavior Read More »

https://www.jneurosci.org/content/early/2023/03/06/JNEUROSCI.1982-22.2023.long I’m metaphorically screaming right now. This is the piece of confirmatory evidence I’ve been waiting for since I saw this. Something I really love about this particular work is it demonstrates a homeostasis point, “too much” is as important a mechanic as “too little”. Only doing a knockout isn’t enough to really understand the …

Differential effects of astrocyte manipulations on learned motor behavior and neuronal ensembles in the motor cortex Read More »

Sorry another stub for now. Sparked by this study Association between mitochondria-related genes and cognitive performance in the PsyCourse Study (which is a bad study with the right idea), we should be able to measure all components of cognitive ability via metabolic interactions, including things like g. As information processing in general is the product …

Measuring cognitive performance via metabolics Read More »

Aquaporin water channels affect the response of conventional anticancer therapies of 3D grown breast cancer cells Aquaporins in Nervous System Cerebral Microcirculation, Perivascular Unit, and Glymphatic System: Role of Aquaporin-4 as the Gatekeeper for Water Homeostasis Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases Cellular Distribution of Brain Aquaporins and Their …

Is glymphatic clearance a far more significant perturber/modifier of nervous system molecule interactions than assumed? Read More »

https://safjan.com/pros-and-cons-of-reliance-on-ai-generating-models/#pros-and-cons-of-reliance-on-ai-generating-models I think the “AI” tie in is dumb, but the underlying question, whether or not our cognitive skills are trainable and evolving vs. the fixed physiologically encoded things that cogsci assumes is a really interesting question. Are we as a species self selecting individuals with an entirely new class of information processing capabilities that …

New Cognitive Skills in the Age of AI Tailored Information Presentation Read More »

I realize that over the last few weeks I’ve left quite a few open posts that I should probably complete. I’ve been having sleep issues the last month (well my kids have, therefore I do as well) so my mental energy has been kind of in the toilet (glymphatic system hasn’t had the opportunity to …

Semi-Apology Read More »