Goodnight, astrocyte: waking up to astroglial mechanisms in sleep
Control of complex behavior by astrocytes and microglia
Ultrastructural view of astrocyte arborization, astrocyte-astrocyte and astrocyte-synapse contacts, intracellular vesicle-like structures, and mitochondrial network
Wow. This is the first time I’ve ever seen any work like this and it’s seriously blowing my mind. This work gives a lot of guidance regarding the how and why astrocytes manage dendritic spines. It also shines a lot of light on just how complex the level of information transfer in inter-astrocyte clusters. It should have been intuitive that this multi-level interaction was occurring but it’s something else entirely to see it. Also kind of cool to see them using Blender for visualization!
From Synapses to Circuits, Astrocytes Regulate Behavior
Hippocampal astrocytes represent navigation space
Astrocytic responses to high glucose impairs barrier formation in cerebral microvessel endothelial cells This is a great gap filler! The bridge between Diabetes Type III and all the various functional deficits incurred by obesity and the cellular mechanics which create the etiology.
Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities
Astrocyte regulation of neural circuit activity and network states
Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior (Wow, lots here).
Astrocytic modulation of neuronal excitability through K+ spatial buffering
Astrocytes integrate and drive action potential firing in inhibitory subnetworks Good starting point to examine the functional effect of astrocytes on neurons. This work ended up being supported by later work finding astrocytes control the whole NKA pump.
Ca2+ activity maps of astrocytes tagged by axoastrocytic AAV transfer. (Astrocytes can manage multiple engrams each?!) (Actually this makes sense, this is how they are able to generate comparison maps).
Astrocyte-to-neuron reprogramming for spinal cord repair Reminder that brain is more than the head. And the cells are the same.
Glial cell-Derived, but Not Neuron-Derived, Extracellular Vesicles May Serve as Novel Biomarkers of Acute Sport-Related Concussion Okay, I need to put a gate on these guys work because they’ve pivoted to this astrocyte centric model. Looking at their past issues, it all just looks like histology porn. Wow, this journal is deeply pornographic.
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis