Interesting Journal Articles of the Week: 11/08/2021

Metaplastic Reinforcement of Long-Term Potentiation in Hippocampal Area CA2 by Cholinergic Receptor Activation

So this hits for a couple of different reasons. First, I think it makes an argument that anxiolytic drugs work by essentially turning off the ability to process social information (“learn”).

This suggests that such bidirectional synaptic modifications triggered by the dynamic modulation of tonic cholinergic receptor activation may support the formation of CA2-dependent memories given the increased hippocampal cholinergic tone during active wakefulness observed in exploratory behavior.

Second, blah blah dorsal/ventral stream.

CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish

Behavior is generated by energy flows in the brain. Most of the circuitry of the brain is designed to manage those flows to produce desired behavior. This is a piece of evidence toward this argument, we are seeing reduced flow of energy in certain areas change global behavior.

Increased Functional Connectivity of the Intraparietal Sulcus Underlies the Attenuation of Numerosity Estimations for Self-Generated Words

“Hyper-connectivity” and/or “hyper-myelination” are phenotypes of “autism”.

Trial-to-Trial Variability of Spiking Delay Activity in Prefrontal Cortex Constrains Burst-Coding Models of Working Memory

Working memory/Executive Function are bullshit constructs. Constantly finding heterogeneity in the models of these constructs is expected.

Differential Effects of Cerebellar Degeneration on Feedforward versus Feedback Control across Speech and Reaching Movements

I’m kicking around the idea of repacking the dorsal/ventral concept as a dysmetria concept. Because brains are designed to perceive a single stream, studies like this which view feedforward and feedback systems as a single stream with two parts might be a more approachable entry point.

Common and Unique Inhibitory Control Signatures of Action-Stopping and Attentional Capture Suggest That Actions Are Stopped in Two Stages

Dorsal/Ventral blah blah.

Neocortex saves energy by reducing coding precision during food scarcity

Why are school nutrition programs important? Why does SES impact cognitive performance so heavily?

Brain rhythms define distinct interaction networks with differential dependence on anatomy

Yep.

Transcriptional and functional divergence in lateral hypothalamic glutamate neurons projecting to the lateral habenula and ventral tegmental area

Blah blah Dorsal/Ventral.

CA2 inhibition reduces the precision of hippocampal assembly reactivation

A look at the delusion, one part of the elephant at a time.

Re-conceptualizing domains in neuroscience, hopes and utopias aside

Describing cognitive processes without reference to their neural underpinnings has led to conceptualizations that do not match how the brain functions.

snark snark snark no fucking shit sherlock snark snark