Is glymphatic clearance a far more significant perturber/modifier of nervous system molecule interactions than assumed?

• Can we measure something like “kinase clearance”?
• Could we identify systemic issues with a test similar to glucose testing?
• How do regional variations of clearance impact performance? Can you have “tired eyes” but “excited social module”? Excited heart but tired kidney?

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Aquaporin water channels affect the response of conventional anticancer therapies of 3D grown breast cancer cells

Aquaporins in Nervous System

Cerebral Microcirculation, Perivascular Unit, and Glymphatic System: Role of Aquaporin-4 as the Gatekeeper for Water Homeostasis

Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases

Cellular Distribution of Brain Aquaporins and Their Contribution to Cerebrospinal Fluid Homeostasis and Hydrocephalus