Is the etiology of most degenerative/dementia related conditions a family of calcium binding issues?

Edit: What’s the difference between drunk and demented on small timescales?

I’m wondering what the range of calcium channel performance looks like across a population. What do the phenotypes for Ca2++ and Ca2– look like?

Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance