Ugh. This really doesn’t look good so far.
Still looking for work regarding heat shock response longitudinally. With brains running warmer than previously understood in core areas, this may be a significant issue going forward. Are humans even fully adapted to climate as warm as now yet? Skeptical here.
There should be certain professions more likely to be exposed to consistent higher temperatures, need to think about how to setup a null case – maybe office workers adjacent to those professions? Honestly the protein folding errors commonly seen in heat shock look a lot like plaques associated with dementias.