Eukaryote cells are hybrids, they use both anaerobic and aerobic metabolic components.
Aerobic processes allow for more raw energy, sustained over time.
Underlying those processes are anaerobic processes, which are the basis nuclear<->cytoplasmic metabolic interactions.
We need a way to accurately measure these processes outside of assumptions derived from BOLD style conceits.
Got sidetracked thinking about lactated ringers components, each component of which is pretty critical for intracellular signalling. In between that signalling is the transition between anaerobic and aerobic metabolic processes.
And then my brain went to thinking about free divers and how with effort they massively expand their anaerobic energy capacity and efficiency, something that we very rarely focus on outside of a few other sports (body building would be one of the few).
I have a hunch that the effectiveness of many nervous system treatments, and indeed a large amount of effect of drugs (or potential peptide/RNA solutions) may depend on how deep an individual’s anaerobic well is. Specifically, the deeper the anaerobic well, the larger the peptide/protein pool available to a cell.
How do we measure this?