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Future medicine: from molecular pathways to the collective intelligence of the body – Intelligence from the spaces in between. (should note I’m conflicted about one of the authors on this one, great ideas but everything is through an “AI” lens which is interesting but not interesting) The Multiple Realizability of Sentience in Living Systems and …

A collection of assorted works from on our around 11-26-2023, sorted in no particular order, with no particular topic other than the mechanics of expressed biological function. Read More »

One thing that occurs to me when discussing neuroscience generally is how disconnected most of the discussion is from the underlying mechanics of the system being discussed. In fact most neuroscience discussion tends to be *really* bad about the biology part of it, which is probably how it ended up ingesting so many terrible concepts …

Let’s get physical Read More »

Just had an interesting conversation around a post about the results of their genetic test, specifically whether a specific gene (COMT) implies a specific personality or general behavioral phenotype (“Warrior”). In the course of the conversation, it was implied that behavior is “significantly” driven by genes, that complex behavior is heritable, and that environmental effects …

Genes, Genes, the Musical Fruit Read More »

Think of them as an additive and a subtractive set of systems. Hah, “consciousness runs through our veins” quite literally. Wonder how much active work is looking into rolling back immune cells to PSC equivalents? It’s just so weird that human cognitive performance curve over a lifetime looks so similar to immune response strength. It’s …

The “immune system” is an equal weight contributor to cognition, and it has it’s own variance in “intelligence” as astrocyte “intelligence”. [WIP] Read More »

Over the past year one of the tools I’ve been developing is examining any set of information through a lens asking what if the construct being examined was literally anything else? The idea behind this is to assist in forcing generalization of the information being provided. What would happen if we changed the nouns in …

Thought Experiment – Literally anything else Read More »

Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model – Interesting enough topic to make new post. This is one of the more sensical explanations for the mechanics of ketamine vs. “hard” depression, it aids in flushing the intercellular milieu, allowing new behavioral pathways to …

Ketamine and Confusion Read More »

Breathing cluster in complex neuron–astrocyte networks – It’s kind of funny how much work starts off with something equivalent to “We thought astrocytes merely supported neurons, boy were we wrong – but we don’t have the nuts yet to say neurons are support cells yet.” Really fascinating part about this is that it suggests a …

11/15/2023 Humpty Dumpty Read More »

Looks like I posted too many external links to Reddit for a new account and it thinks I’m a bot. Beep bop borp I guess. Welp, luckily the website is here for exactly this contingency. If anyone would be so kind as to post the links for new posts to the sub, that would be …

Panned from Reddit Read More »

Hey there, and welcome. The amazingness that you see before you is a work in progress. At this point we are copying and cleaning up the posts on the [subreddit where this concept started](https://www.reddit.com/r/remodeledbrain), so it’s going to be a bit of a house in a tornado for a bit. So what is all of …

ABOUT Read More »