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Hey there, and welcome. The amazingness that you see before you is a work in progress. At this point we are copying and cleaning up the posts on the [subreddit where this concept started](https://www.reddit.com/r/remodeledbrain), so it’s going to be a bit of a house in a tornado for a bit. So what is all of…

Jist of this is that at that all biological systems are based on repeatable, predictive chemical reactions. Biological systems have a complex set of interacting reactions, however we should be able to scale the predictiveness and repeatability of that chemistry even into human cognitive processes. This foundation also provides some interesting pathways for simplification of…

Direct current stimulation of endothelial monolayers induces a transient and reversible increase in transport due to the electroosmotic effect – This suggests tDCS (when effective) induces the changes in RNA expression by modifying the cellular osmotic pumps, rather than more directly modifying the transcription/translation process. This feels more correct than the model’s assumption of directly…

Astroglial Alterations in the Hippocampus of Rats Submitted to a Single Trans-Cranial Direct Current Stimulation Trial – Lol, I guess I haven’t posted anything about tDCS for awhile but it looks like there’s finally some scant support for my hypothesis about it’s effectiveness. Reading very slightly between the lines, this work implies that tDCS modifies…

Combining S100B and Cytokines as Neuro-Inflammatory Biomarkers for Diagnosing Generalized Anxiety Disorder: A Proof-of-Concept Study Based on Machine Learning – Hadn’t considered using interleukins specifically like this, hrm… Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish – Hahah, “autistic” zebra fish. The role of astrocytes in behaviors related to emotion and motivation…

Can’t find anything on youtube for that title, was a song we sang at summer camp that went something like “Announcements… what a horrible way to die, what a horrible way to die, what a horrible way to spend the day, announcements”. Or something like that. Yes, I bind information directly sensory stimuli, what of…

The placenta epigenome–brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment – Genes are important, but it’s expression that matters. I dunno about the “placenta-brain” axis thing though. Human white matter myelinates faster in utero than ex utero – Heh, white matter is white because of myelination (and fibrous cell types). A new…

Notes to fill in later: Heterogeneity of expression Overlap between ADHD and trauma response Big astrocytes, little connections Conforming to existing data Why does “ADHD” look so much like dorsal flavors of “autism”? Edit: Still working on this. Associations Between Adverse Childhood Experiences and ADHD Diagnosis and Severity – OR isn’t great here, but this…

Association between enlarged perivascular spaces and cerebrospinal fluid aquaporin-4 and tau levels: report from a memory clinic – AQP “over-expresses” in response to misfolds/gunk in an attempt to clear it. Makes sense. Control of blood capillary networks and holes in blood-brain barrier models by regulating elastic modulus of scaffolds – It’s just physics baby. Hypothalamic…